Mild Cognitive Impairment Study

Working memory and frontal white matter ingetrity in mild cognitive impairment

This study involves memory testing and an MRI performed on separate occasions. It involves no treatment. The study uses a new MRI technique called diffusion-tensor imaging (DTI). DTI provides more detailed information about the white matter in the brain than can be learned from conventional MRI. White matter lies under the surface of the brain and forms the connections between different brain regions. White matter is critically important to the brain working in an integrated functioning. White matter circuits in the front of the brain are important for abilities such as planning, problem solving, and keeping track of information over time. We are studying the relationship between how people perform on tests of these thinking abilities and the health of frontal white matter measured with DTI. The results might help identify individuals who are at highest risk for developing Alzheimer's disease.

For more information on this study, please contact Dr. Stephen Correia at 401-455-6403.